Pan-cancer noncoding genomic analysis identifies functional CDC20 promoter mutation hotspots
نویسندگان
چکیده
منابع مشابه
Pan-Cancer Analysis of Mutation Hotspots in Protein Domains.
In cancer genomics, recurrence of mutations in independent tumor samples is a strong indicator of functional impact. However, rare functional mutations can escape detection by recurrence analysis owing to lack of statistical power. We enhance statistical power by extending the notion of recurrence of mutations from single genes to gene families that share homologous protein domains. Domain muta...
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ژورنال
عنوان ژورنال: iScience
سال: 2021
ISSN: 2589-0042
DOI: 10.1016/j.isci.2021.102285